Friday, November 29, 2019

Six Exercises to Improve Writing Clarity

Whether you’re writing a blog post, a newsletter or a white paper, it’s essential to get your message across quickly and in a way that is easy to understand. If you don’t, readers will stop reading or skim your content. With verbal communication, you can use body language, facial expressions and vocal tone to get your message across. But when you write, you only have words. Most writers agree that to become a better writer you must read and write a lot. But there are also a few exercises your can do to further flex your writing â€Å"muscle.† Here are six exercises to help you tighten up your writing and produce more compelling content. How to Add Clarity to Your Writing When you have a message to give, it’s imperative that nothing about that message is muddled. How can you go about being more clear in your writing? Be Specific Think of all the homonyms (words that are spelled the same but have different meanings) in the English language: crane, date, dog, rose, type – the list goes on. A dog could be an animal, but it could also be a wicked person. And there are thousands of different breeds of the animal (there’s a range of differences between a bulldog and a great Dane). By being specific, you’ll make sure that the reader isn’t confused by your message. Use Positive Language The word â€Å"not† gets thrown around quite a bit in writing. With some revision, however, we can spin those â€Å"not† phrases into something more positive and interesting. For instance, â€Å"not known† becomes â€Å"unknown† and â€Å"Not interesting† becomes â€Å"boring.† It’s a small change, but it will subconsciously keep your readers reading. Avoid Wordiness Writers sometimes fall into the trap of padding their word count with repetition. But precision is more important that word count most of the time. Think about what words you’re using. Writing should be more like archery than shooting a machine gun; preciseness is more impressive than just spraying words around and hoping something sticks. 6 Writing That Will Improve Your Writing Clarity 1. Tweet More Tweeting forces you to sharpen up your writing because you have only 140 characters to communicate your message. You have to be more direct. The last paragraph was only 140 characters, but it explained why Twitter can be an effective tool for writers. It makes you focus on the reader and get your point across in as few words as possible. 2. Explain a Complex Subject in 100 Words or Less This is actually a more difficult exercise than it sounds. If you need some inspiration, check out HubSpot’s â€Å"In Under 100 Words† series, which addresses some complicated subjects in short form. Choose a subject you love or one you know very little about. Remember to include as much information as possible, without being vague. 3. Write a Sonnet or Haiku Choose a topic and then explain it within the framework of a sonnet. This is a poem of fourteen lines, using ten syllables per line. If you’re feeling brave, try writing a haiku. This is a poem of seventeen syllables, in three lines of five, seven and five. The poems don’t have to rhyme, but they force you to make every word count. They also make you to consider how words sound and how sentences flow together. 4. Summarize an Article Take any article from the Internet and summarize it in as few words as possible. Try to include all the main ideas and leave out anything that is not essential. Not only will this help you write more concisely, it will help you recognize waffle in other people’s writing as well as your own. 5. Write a Flash Fiction Story Flash fiction stories can be anything from 100 to 1,000 words. When you try to write a complete story in so few words, it makes you think about the beginning, middle and end. It also forces you to cut out unnecessary details and use words that convey more emotion and meaning. 6. Edit Someone Else’s Writing If you have no trouble getting words on the page but you think your finished content needs tightening up, try an editing exercise. Find a blog post online and copy the text into your text editor. Then look for as many ways to improve it as you can. Check for the following: Spelling or grammatical errors. Long sentences that can be shortened. Unnecessary words. Formatting problems. Confusing ideas that could be made clearer. Remember to take away the positive aspects of the writing, which will help improve your own style. Techniques for Writing Clarity 1. Strong introduction A good introduction to an essay explains what will follow, and this strategy is no less powerful in all forms of writing. Telling the reader what to expect will help them follow your logic and understand your ideas. 2. Proper formatting Formatting text correctly is often overlooked by writers, but it’s a powerful technique. A headline in bold will emphasize a key point. Bullet points will help to clarify your ideas. And an italicized word will clarify your tone of voice. 3. Focus Focus on one idea per paragraph. It helps to break down your content into distinct ideas, making your overall message clearer. It also gives readers time to digest each point you make. 4. Avoid Jargon Remember your audience. Your readers may not know as much as you do about your area of expertise. So, drop the jargon and use simpler words whenever possible. Clear communication means the reader should never have to look up a word in the dictionary. 5. Use an Active Voice Avoid the passive voice as it weakens your message. For example, write â€Å"Our company received an award,† not â€Å"Our company was chosen to receive an award.† Never Be Complacent Generally, clear writing means getting to the point as quickly as possible. It’s about knowing what you want to say before you start writing. It involves using simple words and uncomplicated sentences to express your ideas and help your readers understand your ideas. Keep these tips in mind before your next writing project. Hopefully, these techniques and exercises will improve your writing clarity, help you communicate more powerfully and leave your readers engaged and hungry for more.

Monday, November 25, 2019

Persian Battle at Thermopylae in 300 Movie

Persian Battle at Thermopylae in 300 Movie Thermopylae (lit. hot gates) was a pass the Greeks tried to defend in a battle against the Persian forces led by Xerxes, in 480 B.C. The Greeks (Spartans and allies) knew they were outnumbered and hadnt a prayer, so it was no surprise that the Persians won the Battle of Thermopylae. The Spartans who led the defense were all killed, and they may have known in advance that they would be, but their courage provided inspiration to the Greeks. Had the Spartans and allies avoided what was, in essence, a suicide mission, many Greeks might have willingly medized* (become Persian sympathizers). At least that is what the Spartans feared. Although Greece lost at Thermopylae, the following year they won battles fought against the Persians. Persians Attack the Greeks at Thermopylae Xerxes fleet of Persian ships had sailed along the coastline from northern Greece into the Gulf of Malia on the eastern Aegean Sea towards the mountains at Thermopylae. The Greeks faced the Persian army at a narrow pass there that controlled the only road between Thessaly and Central Greece. Spartan King Leonidas was general in charge of the Greek forces that tried to restrain the vast Persian army, to delay them, and keep them from attacking the rear of the Greek navy, which was under Athenian control. Leonidas may have hoped to block them long enough that Xerxes would have to sail away for food and water. Ephialtes and Anopaia Spartan historian Kennell says no one expected the battle to be as short as it was. After the Carnea festival, more Spartan soldiers were to arrive and help defend Thermopylae against the Persians. Unfortunately for Leonidas, after a couple of days, a medizing traitor named Ephialtes led the Persians around the pass running behind the Greek army, thereby squashing the remote chance of Greek victory. The name of Ephialtes path is Anopaea (or Anopaia). Its exact location is debated. Leonidas sent away most of the amassed troops. Greeks Fight the Immortals On the third day, Leonidas led his 300 Spartan hoplite elite troops (selected because they had living sons back home), plus their Boeotian allies from Thespiae and Thebes, against Xerxes and his army, including the 10,000 Immortals. The Spartan-led forces fought this unstoppable Persian force to their deaths, blocking the pass long enough to keep Xerxes and his army occupied while the rest of the Greek army escaped. The Aristeia of Dieneces Aristeia relates to both virtue and the reward given the most honored soldier. In the Battle at Thermopylae, Dieneces was the most honored Spartan. According to Spartan scholar Paul Cartledge, Dieneces was so virtuous that when told there were so many Persian archers that the sky would grow dark with the flying missiles, he replied laconically: So much the better we shall fight them in the shade. Spartan boys were trained in night raids, so although this was a show of bravery in the face of countless enemy weapons, there was more to it. Themistocles Themistocles was the Athenian in charge of the Athenian naval fleet that was nominally under the command of the Spartan Eurybiades. Themistocles had persuaded the Greeks to use the bounty from a newly discovered vein of silver at its mines at Laurium to build a naval fleet of 200 triremes. When some of the Greek leaders wanted to leave Artemisium before the battle with the Persians, Themistocles bribed and bullied them into staying. His behavior had consequences: Some years later, his fellow Athenians ostracized the heavy-handed Themistocles. The Corpse of Leonidas There is a story that after Leonidas died, the Greeks tried to retrieve the corpse by means of a gesture worthy of the Myrmidons trying to rescue Patroclus in the Iliad XVII. It failed. The Thebans surrendered; the Spartans and Thespians retreated and were shot by Persian archers. The body of Leonidas may have been crucified or beheaded on Xerxes orders. It was retrieved about 40 years later. Aftermath The Persians, whose naval fleet had already suffered seriously from storm damage, then (or simultaneously) attacked the Greek fleet at Artemisium, with both sides suffering heavy losses. According to the Greek historian Peter Green, the Spartan Demaratus (on Xerxes staff) recommended splitting the navy and sending part to Sparta, but the Persian navy had been too heavily damaged to do so fortunately for the Greeks. In September of 480, aided by northern Greeks, the Persians marched on Athens and burned it to the ground, but it had been evacuated.

Thursday, November 21, 2019

GENE THERAPY, HUMAN GENOME PROJECT, CLONING Assignment

GENE THERAPY, HUMAN GENOME PROJECT, CLONING - Assignment Example These retroviruses then help to code for the infected DNA which can then form or remove a gene accordingly. In general there are two types of gene therapies known as the germ line therapy and the somatic gene therapy. In germ line therapy a gene is directly inserted into the egg or sperm so that the gene is incorporated into the original genes. In somatic gene therapy the genes are inserted into the somatic cells which are spermatozoa and ova cells (Kelly 2007). Gene Therapy has yet not proved to be successful but it can be used in hereditary diseases such as cancer and nervous tissue disorders. Although gene therapy drugs have yet not been introduced in the market as a full, China has allowed a gene therapeutic to be allowed in their market to treat cancers. Gendicine is the name of the drug which can be used for treating cancers in China. Gene Therapy is originally targeted for diseases like leukemia, anemia, hemophilia and other cancers (Guo & Xin 2006; Peng 2005). Human Genome Project was a project launched in the year 1990 by international authorities to find out the sequencing of the human genome along with the identification of the chemical base pairs. The project was completed in 2003 and helped to know much about the structure of the human genome. It is this human genome project which helped to know a lot about the structure of chromosomes, the proteins coded by the genes, and the number of genes in a human being. Human Genome Project has had worldwide recognition but many of the individuals living in the world have also become concerned regarding the results of the project. In some of the societies the project is not ethically accepted because of different reasons. Many individuals believe that the results of the project would help the scientists to make their way through to cloning and other experimentation involving human beings. It is this Human Genome Project which can further excel the

Wednesday, November 20, 2019

Personal Creativity Essay Example | Topics and Well Written Essays - 2250 words

Personal Creativity - Essay Example It is creativity that gives meaning to our lives and it is during the process of creation that we feel life in its highest, most enjoyable form i.e. we feel happy and fulfilled at not only being connected to the highest being of the universe but also being able to benefit the existing universe as a result. But what exactly is Creativity? Is it found in a special class of human beings or is it a quality we all posses? Some definitions of ‘creativity’ explain that the idea behind the term is the conceiving of a new idea.’ â€Å"The word creativity is a noun naming a phenomenon in which a person communicates a new concept (which is the product). Mental activity (or mental process) is implicit in the definition.† (Rhodes, n.d.). ‘Creativity involves being imaginative, going beyond the obvious, being aware of one’s own unconventionality, being original in some way.† (Craft, 2000) â€Å"Creativity is the act of turning new and imaginative ideas into reality. Creativity involves two processes: thinking, then producing.† (Naiman, 2011) Contrary to common belief, we are all involved in various acts of creativity without realizing it. Without creativity, not only would our lives be empty, it may even be a continuous downward spiral as life needs creative input. At every step of our lives we have to do something new to change for the better. It can be as simple as trying out a new route to work in order to create a shortcut and save time. Or taking the risk of adding an extra ingredient to enhance the taste of something you’re cooking. Creativity is not accepting things just as they are, but in order to improve them, striving for new ideas. Thus creativity is present in all of us at some level and it comes to use when there is some problem to be solved. According to Nomura Institute of Japan, we are presently living in the era of Creativity, where constant innovation is required for us to be able to survive (Naiman, 2011). This statement proves itself as we take a look around and see how the economy and the com petitiveness surrounded by it have resulted in a need for change in all fields of work. Followed by the Agricultural, the Industrial and then the Informational age (Naiman, 2011), the age of Creativity looks for the New and the most Efficient. In this age anything, even a light bulb that produces less than it is given as an input, will be thrown out of the race and only the fittest will survive. Therefore every field of knowledge has increased pressure on research to keep up, and thus we see a faster pace of development. Along with the quantity we also have much better quality. With economic and environmental sustainability in mind, more responsible technology, education, designs and services are produced in all areas of life. In spite of what I’ve said about the everyday nature of creativity, when it comes to the working environment, where there is competition, not everyone stands at the same level. There are the original genius’s who seem to make everything work in w ays so simple they surprise us. Then there are others who have followed every rule, have stuck to routines that ensure maximum productive time and yet they’re work, although detailed and complete fails to bring to attention anything new, thus lacks creativity. This can be very commonly observed in creative fields such as art and design of which I am a part and have worked through various types of creative processes. People who are more creative in nature than others usually have a certain type of personality i.e. they have certain traits that distinguish them from others. The first

Monday, November 18, 2019

Postoperative Nausea and Vomiting Essay Example | Topics and Well Written Essays - 2750 words

Postoperative Nausea and Vomiting - Essay Example Clinically, however, there is a serious need to control PONV since undertreated, PONV may lead to life-threatening complications, such as, wound dehiscence, pulmonary aspiration of gastric contents, bleeding, dehydration, and even electrolyte imbalances if continued unabated. Rapid advances in surgical techniques have brought in a paradigm shift in approach to surgical practice, where the order of the day is minimal access and rapid discharge from the hospital, and day care surgeries are rapidly replacing the convention surgical practice of prolonged hospital stay. Even very mild PONV may result in delayed hospital discharge, decreased patient satisfaction, and increased use of resources including medical and surgical care, intravenous fluids, drugs, and other supplies. PONV is the major cause of unanticipated admission to hospital following day-case surgery (Gan, 2006), and from these angles, prevention and management is of utmost importance, and for the reason given above, the nurs es must implement the management strategies that consider evidence from research. Nurses have responsibilities to prevent and relieve postoperative nausea and vomiting. ... Most of the nursing practice for management of PONV goes by traditional practice, not by evidence. Classically a majority of PONV is caused by the effects anesthetic agents on the brain and other related perioperative factors. With the advent of newer pharmacologic agents that are used to induce anesthesia, it is now important to update knowledge on the management of PONV. There is a huge body of literature of PONV management that covers pharmacological, dietary, and behavioral interventions that may culminate into an updated development of assessment and management guidelines (Eberhart et al., 2004). Moreover, it will open an opportunity to identify the gaps in knowledge, so further research can be carried out. Therefore it was decided that a literature review will be undertaken to find out evidence from published research literature in the current time to examine evidence and rationale for nursing practices in PONV, and the findings will be presented in an organized manner so these can be utilized as a guideline in the practice. Strategy of Literature Review To build a scientific basis of evidence, a comprehensive literature search was undertaken and then evaluated. For the purpose of the review of literature to support the rationale, need, and continuation of the project, the author conducted an exhaustive literature search. Electronic databases accessed for information included: CINHAL, Medline and Pubmed along with the Google Scholar internet search engine. Moreover MEDLINE, EMBASE, and CINAHL and Cochrane databases were searched to identify relevant literature on prevention and management of Postoperative nausea and vomiting. UMI Proquest Digital Dissertations, ISI Web of Science, Cambridge Scientific Abstracts,

Saturday, November 16, 2019

Wet Granulation Advantages And Disadvantages Biology Essay

Wet Granulation Advantages And Disadvantages Biology Essay In this lab three different sets of tablets were produced i.e soft, medium and hard using different processes which mainly included i.e Direct Compression Vs Wet Massing ,different excipients which included (Lactose Vs Calcium Phosphate) and different binders which included (PVP Vs Klucel). Once all the tablets were produced by the above mentioned varying processes, excipients and binders they were studied and compared to see how they would influence a range of tablet testing parameters such as uniformity of weight, friability, crushing strength disintegration time. Introduction: A tablet is perhaps the oldest and the most common pharmaceutical dosage form. Its popularity is due to its convince in the administration of the drug without the help or supervision of a health care practitioner, thus providing patients freedom and a very cost effective means of providing a reproducible medication. A tablet seldom consists of only the active ingredient. In fact , a tablet represents a mixture of one or more active ingredients with a number of inactive ingredients or excipients. There are many reasons for formulating a tablet product with excipients, ranging from management of small dosage amounts of active ingredients to esthetic resons of colour and shape of a product. However, the most fundamental and critical objective of a tablet product is to provide/deliver the active ingredient accurately and reproducibly. Therefore, from this perspective, a tablet is now commonly considered as a drug delivery device (Ahmed, 2000). However all tablets are made by compressing a particulate solid between two punches in a die of a tablet press. For an active ingredient to be transformed into tablets of satisfactory quality , the formulation must have three essential attributes. First, the formulation must flow into the die space of the tablet press sufficiently rapidly and in a reproductible manner Second, the particles in the formulation must cohere when subject to a compressing force, and that coherence should remain after the compressive has been removed. Third after the compression event is complete, it must be possible for the tablet to be removed from the press without damage to either the tablet or the press. Very few active ingredients possess all three of these essentials and some posses none of them. Hence some preliminary treatment is almost invariably necessary. Methods of Tablet Manufactures: There are three main methods of tablet manufacture designed to confer the above mentioned essential attributes to a tablet formulation. Wet granulation and direct compression are the most important, with dry granulation (also termed as precompression or slugging) used in some circumstances. Fig shows the processes of wet granulation and direct compression broken down into their constituent stages. The relative simplicity of the direct compression process is immediately apparent. Ease of removal of the tablet from the press is, in theory at least, readily achieved. Friction occurs between the tablet and the die and punches of the press, which can be overcome by including a lubricant in the formulation. Hence every formulation, irrespective of the method of manufacture, will include a lubricant . This will usually be a metallic salt of a fatty acid such as magnesium stearate. The two other prerequisites-flow and cohesion-can only be achieved by more elaborate technique and are in fact the reasons why wet dry granulation processes were devised. As part of its complexity, wet granulation involves the addition of a liquid (usually water), followed by its removal, normally by evaporation. In addition to the energy requirements of this drying process, the presence of water might bring about hydrolysis of the active ingredients, which will be exacerbated at the elevated temperatures used for drying. If a major component of the formulation such as the diluents were to possess the necessary degree of fluidity and compressibility, granulation would be unnecessary. This is the basis of direct compression method of tablet manufacture. Wet Granulation: Advantages and Disadvantages: The wet granulation process is the traditional method of manufacture and is frequently used in the pharmaceutical industry. Expertise in wet granulation is widely available, as in the required equipment. The process improves flow and cohesion reduces dust and cross contamination and permits the handling of powder blends without loss of homogeneity. Though it has been practiced for many years and therefore may be perceived as an old fashioned process., it must be borne in mind that the wet franulation process has itself undergone a transformation in recent decades. High-speed mixer-granulators, fluidized bed granulation and drying and an ever increasing use of automation have served to make wet granulation a much more efficient and economic process than it once was( Marinelli, 2009). Nevertheless, the wet granulation process still retains many inherent disadvantages. Problems include choice and method of addition of the binder and the effect of drying time and temperature on drug stability and its distribution within the solid mass. Direct Compression Process: Advantages and Disadvantages The most striking feature of the direct compression process is its simplicity and hence economy. Less equipment is required and the number of stages in the process, each of which will require validation, is greatly reduced. There are also lower labour costs, reduced processing time and lower power consumption. On top of that since direct compression is a dry procedure therefore there would be no need for a drying stage. Thus, exposure to water and the elevated temperatures needed to remove that water are avoided, resulting in a decreased risk of deterioration of the active ingredient. A further advantage of DC is that tablets disintegrate into their primary particles rather than granular aggregates. The resultant increase in surface area available for dissolution should result in faster drug release. On the other hand talking about disadvantages, the primary limitation on the use of direct compression is that it depends on the fluidity and compressibility of tablet diluents. Therefor e it cannot be used for low potency, high dose active ingredients, where the inclusion of sufficient diluents in the formulation to permit direct compression would lead to unacceptably large tablets. Thus, active ingredients such as paracetamol and aspirin do not tend themselves to the DC process. However, as stated earlier, such ingredients are often available in pregranulated form (Holm, 2009) Thus considering the different ways to produce tablet it is also important to mention here that there has also been an increased emphasis in developing tablets that provide controlled disintegration/release process of the active ingredient.. These tablets are hence known by different names such as slow,extended, controlled, sustained or delayed release tablets to reflect their drug release characteristics. These modified drug release products provide further convenience to patients by reduced frequency of drug administration, thus increasing the chance of compliance as well. However for establishing the quality of a tablet product, the fundamentals remain the same i.e to ascertain that the product delivers the intended active ingredient in an accurate and reproducible manner. Therefore, tablet testing can be broadly divided into three aspects or categories: Confirmation of the nature of the active ingredient and the product ( Identity, quantity, impurities, integrity etc) Establishing pharmaceutical availability of the active moiety both in vitro and in vivo in humans and if required also in animals. Establishing stability profiles to achieve shelf life. Testing of nature of the tablet products: As a consequence one seeks to establish whether the tablets are within specifications, for example the nature of the active ingredients (identification) expected amount (assay) purity (related compounds) and uniformity of the amount of drug from tablet to tablet (uniformity of dosage units). Commonly these testing procedures are described in pharmacopeias under a specific name. In addition to these tests some other tests such as friability, hardness, disintegration etc are also conducted and will be described as below Uniformity of Dosage Units (B.P Pharmacopoeial Tests) This test is conducted to establish consistency in the content of active ingredient from tablet to tablet. There are generally two approaches taken in establishing this: weight variation or content uniformity. If the active ingredient represents not less than 50% weight of the tablet and greater than 50 mg, then one may establish uniformity of dosage units using the weight variation method. A sample of 10 tablets are weighed individually and results of these weighing are recorded. In the case of the content uniformity approach, a sample of 10 tablets are individually analyzed using the analytical method described under the assay procedure. It is mandatory to use content uniformity for tablets with less than 50 mg of active ingredient and/ or representing less than 50% total mass of the tablets. The content uniformity approach is preferred over the weight variation approach as it more precisely reflects the variation of the active ingredient from tablet to tablet. The required specifi cation for this test is that uniformity of dosage unit should be within a range of 85%-115% with a relative standard deviation of less than or equal to 6% (Holm, 2009) Friability ( Non B.P Pharmacopoeial Test) This test is intended to determine, under defined conditions, the friability of uncoated tablets, the phenomenon whereby tablet surfaces are damaged and/or show evidence of lamination or breakage when subjected to mechanical shock or attrition. Commercially available apparatuses known as friabilators are used for the test. Basically, it consists of a drum with diameter between 283mm and 291mm and having width of 36 mm-40 mm, made of transparent plastic material The drum is attached to the horizontal axis of a device that rotates at 25_1 rpm. The tablets are tumbled at each turn of the drum by a curve projection with an inside radius of 75.5 mm-85.5mm that extends from middle of the drum to outer wall. Thus, at each turn, the tablets roll or slide and fall onto the drum wall or onto each other. Usually, a sample of 10 tablets are tested at a time, unless tablet weight is 0.65 g or less, where 20 tablets are tested. After 100 turns, the tablet samples are evaluated by weighing. If the reduction in the total mass of the tablets is more than 1%, the tablets fail the friability test. Generally, the test is done once. If cracked, cleaved, or broken tablets are obvious, then the sample also fails the test (Marinelli, 2009). Hardness Testing ( Non B.P Pharmacopoeial Test) A tablet requires a certain amount of mechanical strength to withstand the shocks of handling in its manufacturing, packing, shipping, and dispensing. As discussed before, hardness and friability are most common measures used to evaluate tablet strength. The need for testing hardness or crushing strength, in addition to friability, may be explained with an analogy that friability determines how fragile a tablet is. If a tablet is more fragile than expected, then the friability test will detect its substandard quality. However, on the other hand, if the tablets are more robust than desired, a friability test would not detect this deficiency. It is the tablet hardness test that will detect the deficiency (Holm, 2009) Disintegration Test (B.P Pharmacopoeial Tests) A disintegration test is a test to establish how fast a tablet disintegrates into aggregates and/or finer particles. The test assumes that if product disintegrates within a short period of time, such as within 5 min, then the drug would be released as expected and one should not anticipate a problem in the quality of a drug product. Although this test is in use for some products in pharmacopeias, its use is generally diminishing in favor of drug dissolution testing (Holm, 2009) Materials Methods: Please refer to the Pharmaceutics Handbook for MPharm Year2 4.0 ) Results Discussion: A fundamental quality attribute for all pharmaceutical preparations is the requirement for a constant dose of drug between individual tablets. In practice, small variations between individual preparations are accepted and the limits for this variation are defined as standards in pharmacopoeias. For tablets, uniformity of dose or dose variation is tested in two separate tests: uniformity of weight and uniformity of active ingredient. These either reflect indirectly or measure directly the amount of drug substance in the tablet. Uniformity of active ingredient: The uniformity of active ingredient is carried out by ensuring a constant dose of drug between individual tablets. Traditionally, dose variation between tablets is tested in two separate tests; 1- Weight uniformity 2- Content uniformity If the drug forms greater part of the tablet, any variation in the tablet weight obviously indicates a variation in the active ingredient. (Weight uniformity test) If the drug is potent (USP specifies 50 mg of the active ingredient or less), the excipients form the greater part of the tablet weight and the correlation between the tablet weight and amount of the active ingredient can be poor, in this case another test (Content uniformity) must be performed (Holm, 2009) In this lab report the weight uniformity test was carried out (which is one of BP requirements) and the following results were obtained. The below table also shows the maximum and minimum percentage error. Table 4.1: Shows the calculated values for CV% along with maximum and minimum % error for various tablets produced by different processes, binders and excipients. Method Excipient Binder Mean / mg Range / mg % Error    CV% Min Max Min Max Direct Compression Lactose 169 164 173 2.95 2.36 1.7 Direct Compression Calcium Phosphate 146 141 148 3.42 1.36 1.5 Wet Massing Lactose PVP 122 120 125 1.63 2.45 1.4 Wet Massing Calcium Phosphate PVP 175 172 179 1.71 2.20 1.2 Wet Massing Lactose Klucel 118 116 119 1.69 0.84 0.9 Wet Massing Calcium Phosphate Klucel 149 142 154 4.69 3.35 2.88 Thus by the help of the above table 4.1 it can be clearly seen that all the tablets produced by different processes, different binders and different excipients are within the percentage max and min error show values below 6% of CV% thus all of them have passed the weight uniformity test. Different Binders: Binders are the substances which are added either dry or in wet- form to form granules or to form cohesive compacts for directly compressed tablets. An ideal binder should have good binding properties, as determined by compressibility under pressure, high plasticity, low elasticity and small particle size. Small particle size facilitates even distribution of the binder through the inter-particulate void spaces in a tablet. Uniform binder distribution in the tablet results in decreased pore structure and subsequent enhancement in tablet crushing strength. To reduce friability, a binder with highly plastic properties (high deformability) is essential. A further requirement for a good binder is low hygroscopicity. Excessive uptake of moisture (greater than 5 percent) or high moisture content can lead to instability and sticking during production (Summers, 2002) There are many excipients used as binders in the direct compression; these include hydroxypropylcellulose (HPC), methylcellulose (MC), povidone (PVP), hydroxypropylmethylcellulose (HPMC), and starches and their derivatives, such as pregelatinized and granulated starches. These polymers differ in their physico-chemical, mechanical and morphological characteristics. For direct compression, studies suggest highly compactable, plastic, fine particle size binders facilitate compression of drugs at relatively low filler-to-drug ratios, therefore representing ideal properties for tablet binders(Summers, 2002) The two different binders that were used in this lab were PVP Klucel XPF. In order to study the effects of different binders the following two figs will be used. Fig one represents the friability disintegration time Vs Hardness for tablets produced by wet massing with PVP as a binder and Lactose as a filler. Fig 4.1) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (PVP) Friability : 1.05 % Hardness: 3.75 Kp Disintegration Time: 2.12 decimal mins The above figure represents the friability, Disintegration time and Hradness for a tablet produced the process of wet massing in the presence of lactose (as an excipient) and PVP as a binder. The value of friability as percentage drops from 2% to about 0.75 % as the hardness increases. This is because as friability is the ability to form fines or fragments of the original tablet and since the hardness of the tablet is increasing therefore consequently less fragmentation of the tablet would occur/ take place. On the other hand however the values for disintegration time augments from 0 to 4.5 with an increase in the value of hardness. This is due to the fact that compacts develop mechanical strength by creation of a surface bonding area between particles. This is mainly achieved by irreversible particle deformation that flattens initial asperity. The decrease of particle surface roughness enables molecular forces to act. Thus, the indentation hardness can be considered as that portion of the compression pressure that contributes to the formation of interparticulate contacts. Accordingly (Hiestand, 2000) proposed the tablet hardness to correspond to the magnitude of the bonding active compression pressure considering these arguments for the strengthening mechanism of tablets, the direct link between hardness and bonding points seems to be a reasonable theoretical approach. Fig 4.2) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (Klucel) Optimum Hardness: 6.5 Kp Optimum Friability: 2.70% Optimum Disintegration Time: 3.45 (time/ decimal mins) The above figure represents the friability, Disintegration time and Hardness for a tablet produced the process of wet massing in the presence of lactose (as an excipient) and Klucel as a binder. From the above figure 4.2 it can be seen that with increased hardness of the tablet the value of the friability drops down. Whereas a direct relationship can be seen between the hardness and disintegration time. Comparing the above two fig 4.1 and 4.2 , it can be seen that fig 4.2 has an optimum hardness value of 6.5 whereas that for fig 4.1 has a hardness value of 3.75 .In a similar fashion there is a difference in the values of optimum disintegration time too with fig 4.2 showing higher disintegration time in comparison to that showed by fig 4.1.This difference in the optimum hardness value is due to the difference of binders. From the obtained results it can be seen that using Klucel results in optimum hardness much high in comparison to when PVP is used. But the value for optimum friability is less i.e 1.05% when PVP is used in comparison to Klucel (friability value is 2.70%). In a similar fashion the values for disintegration time is less for tablets produced by PVP whereas it is high for tablets produced by Klucel . Hence from the results obtained above the PVP seems to be a superior binder in comparison to Klucel in terms of lower friability and less disintegration time period. Fig 4.3) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Calcium Phosphate ) binder (PVP) Optimum Hardness: 5.8 Kp Optimum Friability: 0.78% Optimum Disintegration Time: 0.38 (time/ decimal mins) Fig 4.4) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Calcium Phosphate ) binder (Klucel) Optimum Hardness: 1.4 Kp Optimum Friability: 0% Optimum Disintegration Time: 0.2 (time/ decimal mins) From fig 4.4 it can be seen that the friability behaves quite unexpectedly with increasing hardness. Normally with the tablets, the increase of compression force causes a reduction of friability. The value of friability falls down from 2.75 % to 0 but then starts to rise again as the hardness augments to 5 Kp. One of the possible explanation for this trend could be due to the fact that When the compression force increases, the particles deform plastically and the tablets become harder and less friable But at higher compression forces the friability of the tablets seemed to increase again although the crushing strength remain stable. This could be explained by some fragmentation of the system. Thus again by the help of the above two fig 4.3 and 4.8 it can be clearly seen that the results obtained in this comparison case are opposite to the results obtained by the help of the fig 4.1 4.2. PVP yielded tablets which have higher optimum hardness in comparison to those produced by Klucel. A similar case is with friability and disintegration time too. Thus in this case Klucel stands out to be a superior binder (with respect to low friability and disintegration value). However literarure (Ahmed, 2000) shows that K90 grade for PVP used in this lab (more viscous in comparison to that of Klucel) should produce harder granules. Furthermore using a high grade for PVP like K90 , which is highly viscous, would result in higher dissolution time and hence high disintegration time, which would also consequence in the production of harder tablets. Thus the harder the tablet are the lower friability they would have. Klucel on other hand is less viscous, therefore is will produce softer granules hence softer tablets (therefore low disintegration time and high friability of the tablets will be observed) But this case is not entirely true in all circumstances, as it depends on the grades of the binders used. For example some (Summers, 2002) shows that some grades of Klucel exhibits a unique combination of thermoplasticity with organic solvent or aqueous solubility, allowing tough tablet preparation using many different formulation techniques. Furthermore a tougher binder with a high degree of plastic flow provides better friability performance. In addition, such binder characteristics allow a tableting process to run at a higher compaction speed without capping process. Beyond unmatched tablet hardness and friability, benefits of tableting with Klucel include: à ¢Ã¢â€š ¬Ã‚ ¢ Lower compression and ejection forces; and à ¢Ã¢â€š ¬Ã‚ ¢ Reduction or elimination of tablet capping. On top of this (Boyle) also shows that Klucel can be used at lower use levels to yield superior tablets, compared to tablets with higher binders levels of HPMC, MC, PVP (Grade K 70) and pre-gelatinized starch. (Aqualon) also stated that High-dose acetaminophen formulations using lower levels of poorer binder like PVP (K70) resulted in poorer formulations due to capping. Furthermore, Klucel (Low Grade) has low viscosity due to which it has much lower (almost twice less) the dissolution time in comparison to that for PVP (grade K70). This has a direct impact on disintegration. Thus the lower the dissolution time is, the faster it will disintegrate (hence will show fast effect) (Marinelli, 2009) Different Excipients: In this lab only two different types of excipients were used i.e Lactose and Calcium Phosphate Fig 4.5) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (PVP) Optimum Hardness: 3.78Kp Optimum Friability: 1.1 % Optimum Disintegration Time: 2.15 (time/ decimal mins) Fig 4.6) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Calcium Phosphate ) binder (PVP) Optimum Hardness: 5.80 Kp Optimum Friability: 0.78% Optimum Disintegration Time: 0.38 (time/ decimal mins) By the help of the fig 4.5 and 4.6 it can be clearly seen that the value of optimum hardness (for lactose) 3.78 Kp is quite low in comparison to the value of optimum hardness 5.80Kp for tablets which had calcium phosphate as main excipient. However the same figures also show that lactose has a higher value for friability (1.1%) and disintegration time (2.15 decimal min) in comparison to those showed by calcium phosphate. (Friability 0.78%) and disintegration (0.38 time decimal mins). This difference is due to the fact that lactose is more compressible than calcium phosphate and hence requires less amount of compressible force (as this is what the obtained data suggests). However in real time it has been proposed by (Marinelli, 2009) that calcium phosphate has higher density, hence higher compressibility. Therefore in such a case low compression weight would be required to produce hard tablets with less friability. Whereas in case of lactose it has been suggested that it has lower tap ped density hence poor compressibility. This suggests that at lower pressures it will be elastic and therefore a higher compression weight will be required to produce hard tablets with lesser/lower friability. Fig 4.7) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (Klucel) Optimum Hardness: 6.5 Kp Optimum Friability: 2.70% Optimum Disintegration Time: 3.45 (time/ decimal mins) Fig 4.8) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (calcium phosphate) binder (Klucel) Optimum Hardness: 1.4 Kp Optimum Friability: 0% Optimum Disintegration Time: 0.2 (time/ decimal mins) Thus by the help of the figures 4.7 and 4.8 it can be seen that the results obtained for lactose and calcium phosphate are opposite to the results obtained in figures 4.5 and 4.6. Fig 4.7 and 4.8 show that tablets produced using lactose had high optimum hardness to those produced by calcium phosphate. In a similar fashion the values for friability and disintegration time for tablets produced using lactose were high in comparison to those produced by calcium phosphate. However literature (Marinelli, 2009) suggests that lactose is also more water soluble than calcium phosphate therefore it will dissolve and provide a pathway for diffusion of drug and erosion of matrix, leading to a faster (lower dinintegration time) release of drug from matrix tablets (in comparison to calcium phosphate). Different Processess: The two different sets of processes used in this lab were direct compression and wet massing Fig 4.9) Shows relationship between friability, hardness disintegration time for tablet produced by the process (wet massing) , excipient (Lactose) binder (PVP) Optimum Hardness: 3.78 Kp Optimum Friability: 1.1 % Optimum Disintegration Time: 2.15 (time/ decimal mins) Fig 4.10 ) Shows relationship between friability, hardness disintegration time for tablet produced by the process (Direct Compression) excipient (Lactose) Optimum Hardness: 3.00 Kp Optimum Friability: 0.480 % Optimum Disintegration Time: 0.15 (time/ decimal mins) Thus by the help of the figure 4.8 and 4.9 it can be clearly seen that tablets produced by direct compression show lower optimum hardness, lower value for friability and lower value for disintegration time. Wet massing on the other hand results in tablets formed with high optimum hardness value, high friability value and high disintegration time. It is also worth mentioning at this stage that direct compression process required DC lactose and calcium phosphate of higher grades (Direct compression formulations require good flow in order to maintain proper weight uniformity) whereas low grade regular lactose and calcium phosphate were used for wet massing (during wet massing low grade excipients were used however the granules produced could have been affected by sieving) With regards to wet massing, it is generally agreed that there will exist an optimum range of granule sizes for a particular formulation, and therefore certain generalizations are worthy to note here. Within limits, smaller granules will lead to higher and more uniform tablet weight and higher tablet crushing strength, with subsequent longer disintegration time and reduced friability. The strength of granules has also been shown to influence the tensile strength of the tablets prepared from them, with stronger granules leading, in general to harder tablets (Marinelli, 2009). Conclusion: Fianlly to sum up everything, it was seen in this lab that all the set of tablets produced (hard, soft medium) via different processes or by different excipients or binders , all of them passed the uniformity of weight test. Concerning binders, in this lab PVP seem to stand superior to Klucel (however this might not always be the case). Regarding excipients both lactose and calcium phosphate could be used. As , calcium phosphate has higher density, hence higher compressibility. Therefore in such a case low compression weight would be required to produce hard tablets with less friability. Whereas in case of lactose it has lower tapped density hence poor compressibility. This suggests that at lower pressures it will be elastic and therefore a higher compression weight will be required to produce hard tablets with lesser/lower friability. Lastly , both DC and wet massing were used to produce tablets however tablets produced by DC had shorter disintegration time in compariso n to those produced by wet massing.

Wednesday, November 13, 2019

Cry the Beloved Country :: Cry the Beloved Country Essays

Cry the Beloved Country Cry the beloved country, by Alan Paton, is a book which tells the story of how James Jarvis, a wealthy estate owner who, because of his own busy life, had to learn of the social degradation in south Africa through the death of his only son. If Arthur Jarvis had never been killed, James Jarvis would never have been educated by his sons writings, and Stephen Kumalo. When we first meet james jarvis, he knows little of his sons life. He doesn't know his son "was on a kind of a mission"(p. 140), And this is why when harrison says,"...we're scared stiff at the moment in johannesburg."( p. 140) James is sort of surprised and says,"of crime?"(p. 140). Talking to harrison taught stephen about the crime in the city, and the next morning he learns about his son. One of the first things that james learns of his son, and his views, he learns in arthurs' room. In reading his writings, james finds that arthur would have risked anything to help other people, and ended up doing just that. James finds that his son was well researched on the problems of their society, and was interested in helping the development of the social structure in south africa. From the pictures of jesus and lincoln on his wall, james discovered the admiration arthur had for these two men. These were men of action, who showed love for their friends, and at the same time, their enemies. These two men suffered and died for their beliefs, as did arthur in a way, this is showing arthurs' father what a great man his son was by comparison, and similarity to others. This revelation shows arthurs concern for humanity. After the discovery of his sons views through all of his writings, james begins to realize the problem, and starts to think of the problems of others before his own. In this aspect, james begins to remind the reader of oscar shindler. This is so because shindler was one who at one time hated jews, but as he began to understand them, he thuoght of their troubles and how his wealth could save them. Much like shindler, jarvis helps the minority. Following his sons death and the acquaintance of stephen, james donates 1000 pounds to the african boys club. Jarvis is not just giving gifts in memory of his son, or just to give, but giving those who need help ways to help themselves.

Monday, November 11, 2019

The Financial Detective 2005

[The Financial Detective 2005 Introduction Each industry is distinctive. One might be unique in its high fixed assets; other would be differentiated of its increasing intangible assets and many other financial footprints that each industry leaves on its balance sheet. Nonetheless, industries are distinguished furthermore; fingers of one hand are not the same as said. Businesses in the same industry can be characterized differently according to their strategic plan and capital structure. The following case highlighted some characteristics of different industries and different businesses within those industries. From pharmaceuticals to music and books, those differences, supported by numerical financial data, are explained in the following section. Books & Music General information provided: Company 1 1. Selling through a vast retail-store presence 2. Traditional book retailing 3. Online presence and owns publishing imprint Company 2 1. Sells books, music, videos solely through the internet website 2. Three quarters of the sales are media 3. Sells electronics and other merchandise 4. Recently became profitable 5. Followed a strategy of acquiring retailed online business recently Assessing the provided information about the two companies and looking deeply at some of the financial data, it was concluded that company 1 is designated by the letter H and company 2 is designated by the letter G in Exhibit 1 (see appendix 1). Investigating the financial data, it was found that Company 1 (H) had a higher inventories account of 38. 6 this supports the fact that it is a traditional book store that needed to keep book inventories at all times to maintain its retail presence. This is further seen in its inventory turnover, is has a lower turnover of 2. 2x this reflects the nature of the company which traditional book retailer that experience slow turnover. Moreover, company 1 (H) has an 11. 1 in intangible assets, again this reflects the companies intangible assets such as publishing imprints. Also, company 1 (H) owns about 24. 4 in fixed assets as a results of its vast retail network. For company 2 (G) , inventory account is much lower than company one (14. 8) this reflects the fact that company 2 is online based business that sells mostly digital products such as media along with few other general electronics and merchandise. Thus, its inventory turnover is much higher (13. 56x) correspondent to the nature of most of the sold product (digital media) that are highly demanded and easily accessible. Regarding its fixed assets account, company 2 (b) has lower fixed assets of 7. 6 this mainly reflects the activities related to electronics and other merchandise that probably requires some fixed assets, but for its E-commerce, it needs minimal- none fixed assets. Considering the type of this business (online based) it was noticed that its receivables account is very minimal compared to company 1. This is probably due to the fact that online products are delivered upon payment, thus it is rare to purchase music on credit. Assessing some of the income statements components, depreciation is recognized to be low (1. 1) this is highly related to its low fixed assets. Last but not least, SG& A expenses of 16. 9 is lower than company 1 , this is logical because company 1 depends on a network of retailers that impose higher general and administrative expenses while company 2 depends solely on its o0nline channel. Finally, net profit of 8. 5 (which is higher than company 1) indicates the mentioned recent profitability. Newspapers Information provided: Company 1 1. Centered largely on one product 2. Fierce competition 3. Recently built a large office building for its headquarters. 4. international Company 2 1. Owns a number of local newspapers 2. Has a significant amount of goodwill 3. Recent acquisitions 4. Decentralized decision making and administration Taking a closer look to the provided data, it was concluded that company 1 is designated by letter P and company 2 is designated by letter O (see Exhibit 1) this selection was based on a number of factors: company 1 (P) have more receivables ( 9. ) than company 2 O, this is due to the fact that company 1 (P) operates on a larger, international scale than company 2, this larger customer base requires better and more receivable terms. Whereas company 2 , which operates on a smaller local level has lower receivables of 4. 6. Company 1 (P) has almost the double in fixed assets account t in company 2 (o) (34. 6, 14. 1) explaining the new purchase of th e headquarter building by company (p). Assessing the intangibles account of both companies, it was noticed that company 2 (O) enjoys a high level of goodwill (76. ) while company 1 (P) has far less intangibles of 37. 1. Evaluating company’s 1 (p) focused and centralized strategy of producing and distributing one newspaper internationally, it was noted that this focus led to a decreased cost of goods sold (cost/ unit is inexpensive) this is evidenced in the lower COGS of 40. 5 compared to 49. 7 in company 2 (o). moreover, company’s 1 (P) Debt/ asset ratio is higher than company 2 (O) ( 26. 81 compared to 15. 2) this indicated that it is more cost efficient for company 1 that operates internationally to finance its strategy implementation by using more debt than equity. This boosted the ROE of company 1 to reach 20. 89 relative to a lower ROE of company 2 (9. 86) which follow a more conservative financing mix. As a final point, looking at the SG&A expenses, it was observ ed that company 1 (P) has higher admin expenses due to its strategy of operating internationally while company 2 enjoyed less Admin expenses due to its local strategy ( 39. 7 compared to 23 ).

Saturday, November 9, 2019

Shakespeares Play Reading Course Essay Example

Shakespeares Play Reading Course Essay Example Shakespeares Play Reading Course Essay Shakespeares Play Reading Course Essay If by your art, my dearest father, you have(1) Put the wild waters in this roar, allay them.(2) The sky, it seems, would pour down stinking pitch,(3) But that the sea, mounting to the welkins cheek,(4) Dashes the fire out. O, I have suffered(5) With those that I saw suffer: a brave vessel,(6) Who had, no doubt, some noble creature in her,(7) Dashd all to pieces. O, the cry did knock (8) Against my very heart. Poor souls, they perishd.(9) Had I been any god of power, I would(10) Have sunk the sea within the earth or ere(11) It should the good ship so have swallowd and(12) The fraughting souls within her.(13) This is from Act 1, Scene 2 in Shakespeares comedy The Tempest that is set in the island before Prosperos cell. It is the first time two of the main characters in this play, Prospero and Miranda, are introduced to the audience. In this speech by Miranda, she expresses her strong piteous concern for the people suffered from the sea storm created by her father and her affliction caused by this, which gives us a general idea of this girls personality. Meanwhile, it indirectly puts forward the information that the storm is terribly shocking. As the first speech of this scene, besides expressing the speakers feelings, it also acts as a connecting link between the preceding and the following. There are totally 13 lines in this speech. Seven lines, line 3, 6, 7, 8, 9, 11, and 12, are iambic pentameter, while the rest are not. In one way, it implies though Miranda lives in the island for 12 years, she is still well-educated and entertains the ability to speak properly and nobly. On the other hand, the irregular lines suggests that Miranda is not collected at this moment, worrying and depressed about the direful spectacle of the wreck which touched her strong virtue of compassion inmost. The vehemence of care and sorrow for the wreck is not only expressed by the different length of lines, but also by the punctuations which break the original rhythm of the lines, especially in line 5, 8, and 9 in which a new thought begins in the middle of each line after the full stop, not to mention the higher frequency of the use of comma and colon. It is easy to see that the speaker is not playing with words to show her social status but is in a very situation where language is needed as a mean to interact with her father about one serious issue in relation to several peoples lives. The first imperative sentence is a request to her father for allaying the terrible storm. We are informed that the tempest which gives rise to the crisis in the first scene is not a natural disaster but created by some person who has great power to command the element around him, who can put the wild water in the roar, and also allay them. Meanwhile, the female speaker, the daughter of this mysterious person, disapproves this strongly which is shown by the jussive mood she uses in this sentence. The second sentence gives the audience the descriptions of the scenery in the storm, which has been witnessed by Miranda. Personification is used to help represent the horror of the tempest and make audience feel like they are personally on the scene. The sky could, pour down pitch and have cheeks, the sea is mounting and could dash out the fire. These descriptions vividly show audience the awful scene in the tempest, which deepen the image of the storm that the audience has already gotten from the first scene directly by the reaction of the passenger in the ship. It makes the audience possible imagine a scene in their mind: the sky is dark, the sea is roaring, the ship is cracking in the harsh storm Then Shakespeare used the following two sentences that both begin with the exclamation O to express Mirandas great commiserative concerns and internal grief for the ship and the people in it who are suffering from the storm although Miranda does not know who the people are or why her dearest father tries to destroy the ship. This apparently suggests Mirandas kindness and innocence and gives us a general outline of this only female person character in this play. Miranda also personifies the ship in this speech. It is a brave vessel, has some noble creature in her, it is also a good ship. These words accurately represent the hardship of tempest and express the commiserative feelings of the speaker. Miranda is worrying about the lives of the people in the ship and cannot accept the destruction ordered by her dearest father. The last sentence is a long one consisted of four lines. Miranda hopes she was some god of power and then she can Have sunk the sea within the earth or ere and save the ship and people in the sea storm. The wish sounds childish but heartfelt, shows her strong disagreement with her father and by comparison slightly and indirectly blames her father for being so cruel to those people. The first speech given by Miranda clearly indicates that she is a kind and innocent character. From the following passages we can get the consistent information about her. Miranda has been in this island since she was three. Just as she says: I do not know/one of my sex; no womens face remember/Save, from my glass; my own; nor have I seen/more than that I may call man than you, good friend,/And my dear father: how features are abroad,/I am skilless of she know little about the world outside, the evil in the world or even her own familys story. She is noble mistress, the top of the admiration, So perfect and so peerless, are created of every creatures best! it is natural for such a good girl to feel sorry for the people who are suffering and disagree with her father without knowing the reason that he does so to the people in the wreck. As the connection between the preceding and following, on one hand, this passage echoes with the first scene and gives the audience further descriptions of the tempest; on the other hand, it raises some important questions which are very pivotal to the development of the play, such as what kind of people the speakers father is, how they both got to this island, why her father create the tempest, what kind of relationship the people in the ship and them are and so on. These problems arouse the curiosity of audience and make the plot more compact and gripping. In a word, undoubtedly Shakespeare is a great play writer and a master of language, even though this is a ordinary passage in his play, not as famous as TO BE OR NOT TO BE or other classical pieces in his play, from it, we can still be amazed and gasped in admiration by his ability of making good use of every kind of language skills and excellence in putting a wonderful play on stage.

Wednesday, November 6, 2019

Books on French History

Books on French History This page indexes onsite bibliographic information about French history. General Histories The best one-volume books, plus a bonus for people wanting one book on recent events. A Concise History of France by Roger Price: Part of the Cambridge Concise Histories series, (and so linked to another book on this list), this text is a middle length run through of a fascinating but at times complicated history. The third edition has an extra chapter on very modern France.The Cambridge Illustrated History of France by Emmanuel Le Roy Ladurie and Colin Jones: This is a great one-book summary of France’s history, with a broad range and plenty of visual stimuli.The History of Modern France: From The Revolution to the Present Day by Jonathan Fenby: French history in the post-Napoleonic era is no less interesting than the time before. It is good for the European Union and precursors as well as France. The Best Books Want to start reading about French history, but aren’t sure where to start? We’ve broken down the best books we’ve run on French history and divided them into three lists; we’ve also paid attention to covering as much ground as possible. Pre-Revolutionary France: Top 10France evolved around the turn of the first millennium, but this list goes back to the decline of the Romans to fill in all the eras. Wars against England, wars over religion, and the (possible) apogee of absolutism. The French Revolution: Top 10Probably the turning point around which modern European history revolved, The French Revolution began in 1789, changing both France, the continent and then the world. These ten books include one of my favorite ever history books. Post-Revolutionary France: Top 10French history didn’t end with the defeat of Napoleon, and there’s plenty to look for in the last two hundred years if you want fascinating events and interesting characters. Reviews and Summaries Check out this list of product summaries, that highlight the pros and cons of some stand-out books on French history. The list provides a brief review and lists supplementary detail; many entries also link to full reviews, including the below.​ Citizens by Simon SchamaThis book is a standout among all history books, not just those about French history. This history of the revolution from the early days to the start of the Directory is no less than fascinating but perhaps too baroque for the younger student.​The French Revolutionary Wars by Gregory Fremont-BarnesThe French Revolutionary Wars often get folded into the Napoleonic Wars, so this book that tackles them alone. is well-appreciated.The Oxford History of the French Revolution by William DoyleIf you want to know what happened in the French Revolution, and why, read this excellent work from Doyle. It’s been through several editions, and this is the best student textbook.

Monday, November 4, 2019

Project Planning and Control Essay Example | Topics and Well Written Essays - 2500 words - 1

Project Planning and Control - Essay Example Project management may be defined as the sum total of the functions of conceiving, formulating, scheduling, implementing, supervising, controlling, and reviewing a project with the objective of completing it on time according to specifications and budget. Marion Haynes (2002, p.3) describes project management in the following words: Project management focuses on a project. A project is an undertaking that has a beginning and an end and is carried out to meet established goals within cost, schedule, and quality objectives. Project management brings together and optimises the resources necessary to successfully complete the project. These resources include the skills, talents, and cooperative efforts of a team of people; facilities, tools, and equipment; information, systems, and techniques; and money. Newman, Warren, and McGill defined a project and its value as â€Å"simply a cluster of activities that are relatively separate and clear-cut. Building a plant, designing a new package, soliciting gifts of $500,000 for a men’s dormitory are examples. A project typically has a distinct mission and a clear terminating point†. The multifarious tasks within an organization get simpler and more amenable to effective execution when they are broken up into separate projects that are distinct and specific in terms of cost, time frame, activities, and the project team. As such it is most often likely that a given project remains as a part of a larger organizational project with a longer time frame.

Saturday, November 2, 2019

E-Commerce - Case Study Essay Example | Topics and Well Written Essays - 4250 words

E-Commerce - Case Study - Essay Example Since each party has their own case against each other discussing the cases between parties separately for a better understanding of the issues shall be the norm of this paper. At the end of each case an advice will be given from my contemplation of the merits of each of the case. This case study involves A (Alfred), B (Bert), C (CDE Corporation), Freegames, and Freepcgames portal. Freepcgames is a portal that is involved in providing free computer game programs to its subscribers who pays a monthly subscription fee. Freegames is the local company that represents Freepcgames. It should be noted that Freepcgames.com is a portal registered in the United States. From the facts of the case it is not apparent if the use of Freegames or Freepcgames is a registered trademark or company brand name. Several parties each with their own interest and culpabilities have brought legal actions against one another to protect their rights and legal interests. I shall evaluate the merits of each case between the protagonists and the legal anchors if possible shall be used to provide a solid base for the critical analysis. In some cases I shall provide advice on what charge and the basis of the charges to bring the other party to court. There will be instances wherein I will be providing legal advice or defence for Freegames, since for all intents and purposes Freegames, is my client in this simulated legal situation. The legal advice provided herein remains a theoretical exercise and shall be a hyperbolic representation of an actual legal advice that may be provided to resolve legal issues for Freegames in the future that relates to the instant issues. A (Alfred) vs. Freepcgames.com From the facts of the case it is evident that the whole problem started with Alfred’s use of his company’s resources for personal gain. His case against Freepcgames,com for the recovery of his money shall not prosper because the case arose from his own negligence. A, agreed to the terms and condition of Freegames at the onset and therefore any problem arising from the use of his username and password combination is his responsibility. It should be noted that â€Å"Duty of Care†1 in order for Tort to settle against Freegames the claimant should have his hands dry and clean. Washing his hands of his own culpability and assigning blame to Freepcgames contrary to the tenets of the law and it is against the ambit of human morality. Lord Atkin has set down the test when ‘duties of care’ arises in the following details of Donohue v Stevenson. â€Å"You must take reasonable care to avoid acts or omissions which you can reasonably foresee would be likely to injure your neighbour. Who then, in law is my neighbour? The answers seems to be – persons who are closely and directly affected by my act that I ought reasonably to have them in my contemplation as being so affected when I am directing my mind to the acts or omissions which are called into q uestions†(per Lord Atkin [1932] AC 562 at p 580) It should be noted, that the username, password combination is the established means in which the identity of a person transacting business in the internet is established. With the express understanding of the user or customer of any internet based commercial entity that his username password combination is in fact his identity as far as this internet based commercial entity is concerned. A, therefore is not only expected to be more prudent in